The COVID-19 pandemic has shown that robust safety (and security) mindsets need to be adopted by countries, governments, organisations and other private actors, even individuals, in order to mitigate the spread of COVID-19 and prevent the emergence of future pandemics. Through the years, the civilian nuclear sector has comprehensively promoted a strong nuclear safety culture and a security culture. Adoption of key principles and best practices similar to those used in the nuclear sector to embrace a strong safety culture may help any country or organisation reduce the risk of a catastrophic event such as pandemics. This project explores how nuclear safety culture and even security culture can inform and deepen the Culture of Prevention in ASEAN. It studies how best practices and policies in promoting a nuclear safety (and security) culture can be applied in public health risk mitigation measures and regulation efforts in Southeast Asia.